METABOLIC DERANGEMENTS AS INDICATORS OF PARTIAL HELLP SYNDROME

• Published in: Journal of evolution of medical and dental sciences Vol. 6; no. 84; pp. 5853 - 5856
• Main Authors: Roy, Suparna, Dasgupta, Anindya
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 16.10.2017
• Subjects: Comparative analysis; Health aspects; HELLP syndrome; Pregnant women
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/2017/1271

BACKGROUND Partial HELLP syndrome (PHS) can progress to fully developed HELLP syndrome, eclampsia and its grave consequences if not diagnosed early with subsequent proper monitoring. Studies regarding changes in biochemical parameters in PHS in Eastern India are scarce. MATERIALS AND METHODS This study was a descriptive comparative study. Biochemical and haematological parameters were assayed in 33 PHS cases and 35 control subjects in a case-control hospital-based observational study with an aim to compare their changes with the normal pregnant population. Serum levels of AST, ALT, bilirubin and LDH were measured by standard photometric methods. Blood haemoglobin and platelet count were measured using cyanmethemoglobin assay and automated cell counter respectively. Data were analysed for difference between mean values of study parameters between the case and control group. For assessing the strength of relationship between altered liver function tests and the degree of hypertension, bivariate correlation assay was performed. For all statistical analyses, the P value was considered to be significant at a level of P < 0.05 for 95% confidence interval. RESULTS Serum AST, ALT, indirect and total bilirubin and LDH levels were significantly higher in the case group with P values <0.001. Platelet count was within the normal reference range but significantly lower in the case group when compared to the control subjects. CONCLUSION In our study group, patients with PHS showed significantly higher levels of liver enzymes and indirect bilirubin. In the context of significantly low platelet count, it indicated increased haemolysis in PHS. However, in spite of having higher liver enzymes and increased haemolysis, platelet count was within normal reference interval. In conclusion, we suggest that in our PHS subjects with effective monitoring and early intervention, patients can be saved from poor foetal and maternal outcome of fully developed HELLP syndrome. KEYWORDS Partial HELLP Syndrome, Liver Enzymes, Platelet Count, Hypertension in Pregnancy.