Skip the buffet, for SPARC’s sake

Caloric restriction (CR) reduces inflammation and the incidence of chronic diseases, thereby extending healthspan and lifespan. In this issue of Immunity, Ryu et al. (2022) propose that reduction of SPARC, a matricellular protein, during CR offers beneficial effects by reducing SPARC-driven inflamma...

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Published inImmunity (Cambridge, Mass.) Vol. 55; no. 9; pp. 1583 - 1585
Main Authors Zhai, Lukai, Krawczyk, Connie M.
Format Journal Article
LanguageEnglish
Published 13.09.2022
Online AccessGet full text
ISSN1074-7613
1097-4180
1097-4180
DOI10.1016/j.immuni.2022.08.012

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Summary:Caloric restriction (CR) reduces inflammation and the incidence of chronic diseases, thereby extending healthspan and lifespan. In this issue of Immunity, Ryu et al. (2022) propose that reduction of SPARC, a matricellular protein, during CR offers beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.Caloric restriction (CR) reduces inflammation and the incidence of chronic diseases, thereby extending healthspan and lifespan. In this issue of Immunity, Ryu et al. (2022) propose that reduction of SPARC, a matricellular protein, during CR offers beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.
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ISSN:1074-7613
1097-4180
1097-4180
DOI:10.1016/j.immuni.2022.08.012