Tibetan patients with essential hypertension caused by underlying oxidative metabolism dysfunction and depressed nitric oxide synthesis

• Published in: Chinese medical journal Vol. 116; no. 2; pp. 309 - 311
• Main Author: 李党生 王雄伟 等
• Format: Journal Article
• Language: English
• Published: China 01.02.2003
• Subjects: Adult; Altitude; Endothelium, Vascular - physiology; Female; Humans; Hypertension - etiology; Male; Middle Aged; Nitric Oxide - biosynthesis; NO合成; Oxidation-Reduction; SOD; Tibet; 氧化代谢; 特发性高血压; 西藏患者; Tibet
• ISSN: 0366-6999; 2542-5641

Objecti To assess the role of oxidative metabolism and nitric oxide synthesis for elucidating their pathophysiological mechanisms in Tibetan patient wit essential hypertension. Methods The serum levels of total superoxide dismutase (T-SOD),malondialdehyde(MDA),total antioxidant capacity(T-AOC),nitric oxide(NO)and nitric oxide synthase(NOS) were assayed in sixty native Tibetans(thirty hypertensive patients and thirty healthy volunteers as control).Results The levels of T-SOD,T-AOC,NO and NOS were significantly lower in the patient group than in the control group(P<0.01);MDA was significantly higher in the patient group than in the control group (P<0.01).The level of MDA had a strong negative correlation with T-SOD,T-AOC,NO and NOS (r=-0.82,-0.76,-0.79,-0.73,respectively,P<0.001 for all).Conclusion Tibetan patients with essential hypertension(EH) may have underlying oxidative metabolism dysfunction and depressed NO synthesis,both responsible for the hypertensive process.