The Quantitative Analysis of p-Chlorophenol in Clofibrate
p-Chlorophenol present in various Clofibrate preparation was on determined by colorimetry, using a quantitative method for phenolic OH. This method is based on the widely used technique for colorination of indophenol, modified and adapted for phenolic OH in p-chlorophenol. As a result, a large diffe...
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| Published in | Eisei kagaku Vol. 16; no. 6; pp. 307 - 310 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
The Pharmaceutical Society of Japan
1970
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| Online Access | Get full text |
| ISSN | 0013-273X |
| DOI | 10.1248/jhs1956.16.307 |
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| Abstract | p-Chlorophenol present in various Clofibrate preparation was on determined by colorimetry, using a quantitative method for phenolic OH. This method is based on the widely used technique for colorination of indophenol, modified and adapted for phenolic OH in p-chlorophenol. As a result, a large difference was found in the commercial products of 11 companies. It does not seem that serious trouble will occur even in the product containing highest concentration of p-chlorophenol, but considering high toxicity of p-chlorophenol, it had better be as low a concentration as possible. |
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| AbstractList | p-Chlorophenol present in various Clofibrate preparation was on determined by colorimetry, using a quantitative method for phenolic OH. This method is based on the widely used technique for colorination of indophenol, modified and adapted for phenolic OH in p-chlorophenol. As a result, a large difference was found in the commercial products of 11 companies. It does not seem that serious trouble will occur even in the product containing highest concentration of p-chlorophenol, but considering high toxicity of p-chlorophenol, it had better be as low a concentration as possible. |
| Author | TANNO, KEIKI MORIKAWA, EMIKO WATANABE, KATSUHIRO |
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| References | 2) M. Julia, M. Baillarge, G. Tchernoff, Bull. Soc. Chim. France, 23, 776 (1956) [C. A., 50, 15458 (1948)]. 4) P. Galimberti, A. Defranceschi, Gazz. Chim. Ital., 77, 431 (1947) [C. A., 42, 3361 (1948)]. 3) W. Glynne, M. Jones, J.M. Thorp, W.S. Waring, Brit. Patent 860303 (1961) [C. A., 55, 24680 (1961)]. 9) "Handbook of Toxicology I," W.S. Spector, W.B. Saunders Co., Phil., 1956, p. 68. 15) J.N. Burry, Aust, J. Derm., 9, 142 (1967). 8) Wm. Deichmann, Fed. Proc., 2, 76 (1943). 16) "Brit. Pharmacopoeia," General Med. Council, London, 1968, p.1112. 6) "The Merck Index," 8 th ed., Merck & Co., Inc., U.S.A., 1968. 12) H. Mitsuda, K. Murakami, F, Kawai, Agr. Biol. Chem., 27, 366 (1963). 11) B. Spencer, R.T. Williams, Biochem, J., 47, 279 (1950). 10) A.I. Gurova, Gigiena i Sanit., 29, 37 (1964) [C. A., 62, 4512d (1965)]. 5) T. Leigh, J.M. Thorp, W.S. Waring, "3 rd International Symposium on Drugs Affecting Lipid Metabolism," Milan, Italy, Sept. 1968. 7) "U.S. Dispensatory," 26 th ed., J.B. Lippincott Co., Phil., 1967, p. 804. 14) F. Claude, M. Holtzer, Semaine Hop. Paris, 30, 1553 (1954) [C. A., 48, 13133d (1954)]. 13) H.C. Ansel, D.E. Cadwallader, J. Pharm. Sci., 53, 169 (1964). |
| References_xml | – reference: 2) M. Julia, M. Baillarge, G. Tchernoff, Bull. Soc. Chim. France, 23, 776 (1956) [C. A., 50, 15458 (1948)]. – reference: 10) A.I. Gurova, Gigiena i Sanit., 29, 37 (1964) [C. A., 62, 4512d (1965)]. – reference: 3) W. Glynne, M. Jones, J.M. Thorp, W.S. Waring, Brit. Patent 860303 (1961) [C. A., 55, 24680 (1961)]. – reference: 9) "Handbook of Toxicology I," W.S. Spector, W.B. Saunders Co., Phil., 1956, p. 68. – reference: 4) P. Galimberti, A. Defranceschi, Gazz. Chim. Ital., 77, 431 (1947) [C. A., 42, 3361 (1948)]. – reference: 16) "Brit. Pharmacopoeia," General Med. Council, London, 1968, p.1112. – reference: 14) F. Claude, M. Holtzer, Semaine Hop. Paris, 30, 1553 (1954) [C. A., 48, 13133d (1954)]. – reference: 12) H. Mitsuda, K. Murakami, F, Kawai, Agr. Biol. Chem., 27, 366 (1963). – reference: 15) J.N. Burry, Aust, J. Derm., 9, 142 (1967). – reference: 7) "U.S. Dispensatory," 26 th ed., J.B. Lippincott Co., Phil., 1967, p. 804. – reference: 6) "The Merck Index," 8 th ed., Merck & Co., Inc., U.S.A., 1968. – reference: 8) Wm. Deichmann, Fed. Proc., 2, 76 (1943). – reference: 11) B. Spencer, R.T. Williams, Biochem, J., 47, 279 (1950). – reference: 5) T. Leigh, J.M. Thorp, W.S. Waring, "3 rd International Symposium on Drugs Affecting Lipid Metabolism," Milan, Italy, Sept. 1968. – reference: 13) H.C. Ansel, D.E. Cadwallader, J. Pharm. Sci., 53, 169 (1964). |
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