The Quantitative Analysis of p-Chlorophenol in Clofibrate

p-Chlorophenol present in various Clofibrate preparation was on determined by colorimetry, using a quantitative method for phenolic OH. This method is based on the widely used technique for colorination of indophenol, modified and adapted for phenolic OH in p-chlorophenol. As a result, a large diffe...

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Bibliographic Details
Published inEisei kagaku Vol. 16; no. 6; pp. 307 - 310
Main Authors TANNO, KEIKI, WATANABE, KATSUHIRO, MORIKAWA, EMIKO
Format Journal Article
LanguageEnglish
Japanese
Published The Pharmaceutical Society of Japan 1970
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ISSN0013-273X
DOI10.1248/jhs1956.16.307

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Summary:p-Chlorophenol present in various Clofibrate preparation was on determined by colorimetry, using a quantitative method for phenolic OH. This method is based on the widely used technique for colorination of indophenol, modified and adapted for phenolic OH in p-chlorophenol. As a result, a large difference was found in the commercial products of 11 companies. It does not seem that serious trouble will occur even in the product containing highest concentration of p-chlorophenol, but considering high toxicity of p-chlorophenol, it had better be as low a concentration as possible.
ISSN:0013-273X
DOI:10.1248/jhs1956.16.307