A Case of Juvenile Rectal Carcinoma without a Family History of Colorectal Cancer Accompanied with Mismatch Repair Gene Deficiency

A 28-year-old man admitted for diarrhea was found on palpation to have an elastic hard mass, 10 cm in diameter, was palpated in the lower abdomen. Computed tomography and magnetic resonance imaging showed a solid tumor occupying the pelvic cavity. The preoperative diagnosis was rectal cancer and Mil...

Full description

Saved in:
Bibliographic Details
Published inNippon Shokaki Geka Gakkai zasshi Vol. 36; no. 2; pp. 149 - 153
Main Authors Abe, Tadashi, Shimooki, Osamu, Nakamura, Shin-ichi, Habano, Wataru, Baba, Yuko, Sugai, Tamotsu, Saito, Kazuyoshi, Nomizu, Hitoshi, Yoshida, Toru, Uesugi, Noriyuki
Format Journal Article
LanguageJapanese
Published The Japanese Society of Gastroenterological Surgery 2003
Subjects
Online AccessGet full text
ISSN0386-9768
1348-9372
DOI10.5833/jjgs.36.149

Cover

More Information
Summary:A 28-year-old man admitted for diarrhea was found on palpation to have an elastic hard mass, 10 cm in diameter, was palpated in the lower abdomen. Computed tomography and magnetic resonance imaging showed a solid tumor occupying the pelvic cavity. The preoperative diagnosis was rectal cancer and Miles'operation was conducted. Histopathological diagnosis was well differentiated adenocarcinoma with mucin production (a1, ly1, v1, n0, ow-, aw-, ew-, stage II). High-frequency microsatellite instability (MSI-H) was identified in the rectal specimen using a microsatellite assay. Germline mutation in the h-MSH2 gene was also identified. We diagnosed this case as rectal cancer accompanied with mismatch repair gene deficiency. Assessment of MSI status is important for determing high-risk colorectal carcinoma.
ISSN:0386-9768
1348-9372
DOI:10.5833/jjgs.36.149