Apoptosis in Primary Oral Squamous Cell Carcinomas without Lymph Node Metastases

• Published in: Current medical science Vol. 25; no. 1; pp. 109 - 110
• Main Author: 严志 汪国民 谢志勇 张汉东
• Format: Journal Article
• Language: English
• Published: China Medical Cosmetic Surgery Center, Wuhan First Hospital International, Wuhan 430030, China%Hubei Health Care of Women and Children Hospital, Wuhan 430070, China %Center of Stomatology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China 2005
• Subjects: Adult; Aged; Apoptosis - physiology; Carcinoma, Squamous Cell - pathology; Female; Humans; Lymph Nodes - pathology; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms - pathology; 凋落现象; 原发口腔鳞状细胞癌; 恶化程度; 淋巴结; apoptosis; TUNEL; carcinoma,squamous cell
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/bf02831403

The apoptosis in primary oral squamous cell carcinomas (OSCCs) without lymph node(LN) metastases and its relation with clinical stages and pathological grades was investigated. The terminal deoxynucleotidyl trasferase (TdT)-mediated dUTP nick end labeling (TUNEL) was used to detect the apoptotic cells in 15 cases of OSCCs. The percentage of apoptotic cells among tumor cells were calculated as apoptotic index (AI). The results showed that in all 15 cases of OSCCs,apoptotic cells could be visualized by TUNEL with AI ranging from 0.03 to 0.92 (average 0.32).AI was significantly negatively correlated with pathological grades (P<0. 05). It was concluded that the apoptotic rate was related to the malignant degree of OSCCs without LN metastases.