Changes in platelet parameters and secondary brain injury in acute craniocerebral trauma

• Published in: 中国神经再生研究（英文版） Vol. 6; no. 20; pp. 1543 - 1547
• Main Author: Xiaoping Tang Chao You Hua Peng Tao Zhang Wenguo Tang Jian Qi Renguo Luo Yuanchuan Wang Ling Feng Zhangyang Gou Junwei Duan Shun Li
• Format: Journal Article
• Language: English
• Published: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China%Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China 01.07.2011
• Subjects: 中枢神经系统损伤; 分布宽度; 外伤性; 急性; 手术治疗; 继发性; 脑损伤; 血小板数; platelet distribution width; platelet; secondary brain injury; craniocerebral trauma; mean platelet volume
• ISSN: 1673-5374
• DOI: 10.3969/j.issn.1673-5374.2011.20.004

Changes in platelet parameters are important in secondary brain injury in acute craniocerebral trauma We selected 163 patients with craniocerebral trauma who were admitted within 24 hours with nonoperative therapy. Platelet parameters of 40 healthy subjects served as controls. Platelet number was decreased, while mean platelet volume and platelet distribution width values were increased, at 1 and 3 days after injury. Platelet number was lower and mean platelet volume and platelet distribution width were larger in patients with traumatic cerebral infarction and those in Glasgow Coma Scale score 〈 8 group. Platelet number was negatively correlated to volume of cerebral edema, but positively correlated to Glasgow Outcome Scale score. These data indicate that changes in platelet parameters may be utilized to indicate the state of central nervous system injury and patient prognosis .