Hippocampal functional connectivity and structural changes in Multiple Sclerosis

Methods Resting state functional MR and 3D-T1 images of 30 MS patients (mean age +- SD: 40.6 +- 9.1 years) and 30 age-matched healthy controls (mean age +- SD: 40.5 +- 10.1 years) were acquired on a 1.5T whole-body system (Siemens Sonata). After linear co-registration of hippocampal masks to functio...

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Published inNeuroImage (Orlando, Fla.) Vol. 47; p. S76
Main Authors Roosendaal, S.D., Hulst, H.E., Feenstra, H., Vrenken, H., Castelijns, J.A., Pouwels, P.J., Barkhof, F., Geurts, J.J.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.07.2009
Elsevier Limited
Subjects
Hippocampus
Multiple sclerosis
Patients
Structure-function relationships
Time series
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ISSN1053-8119
1095-9572
DOI10.1016/S1053-8119(09)70506-3

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Summary:Methods Resting state functional MR and 3D-T1 images of 30 MS patients (mean age +- SD: 40.6 +- 9.1 years) and 30 age-matched healthy controls (mean age +- SD: 40.5 +- 10.1 years) were acquired on a 1.5T whole-body system (Siemens Sonata). After linear co-registration of hippocampal masks to functional EPI (shown for a single MS patient in Figure 1A & B), mean left and right hippocampal time series of each subject were extracted (Figure 1C).
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ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(09)70506-3