EXPRESSION OF IMMUNE－RELATED MOLECULES IN GLIOBLASTOMA MULTIFORM CELLS

• Published in: Chinese journal of cancer research Vol. 15; no. 2; pp. 112 - 115
• Main Author: 张学 WalterC.Low 吴安华 王运杰
• Format: Journal Article
• Language: English
• Published: Department of Neurosurgery, China Medical University, Shenyang 110001, China 01.06.2003; Department of Cell Biology, China Medical University, Shenyang 110001, China%Department of Neurosurgery, China Medical University, Shenyang 110001, China%Department of Cell Biology, China Medical University, Shenyang 110001, China%Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
• Subjects: CD80; CD86; β2－微球蛋白; 主要组织相容性复合体; 免疫功能; 多形性恶性胶质瘤; MHC (major histocompatibility complex); GBM (glioblastoma multiform); Immune
• ISSN: 1000-9604; 1993-0631
• DOI: 10.1007/BF02974912

Objective: To investigate the expression of immune-related molecules in glioblastoma multiform(GBM) cells.Methods: The expression of major histocompatibility complex (MHC), β2-microglobulin, Fas, CD80 and CD86 molecules on the surface of GBM cells were evaluated by flow cytometry. The expression of TAP-l, TAP-2 and Tapasin in the GBM cells were evaluated by RT-PCR method. Results: MHC class I, 62 microglobulin, TAP-l,TAP-2 and tapasin were expressed in most GBM cell lines. Except U87, there was no MHC class II molecule expression on any of the other GBM cell lines. Fas was expressed on all the GBM cell lines examined.Conclusion: The mechanism by which GBM escapes immune surveillance may involve down regulation of expression of MHC class I molecules and MHC class Ⅱ molecules. MHC class I positive GBM may be the suitable target of immunotherapy.