Studies on aortic pulse wave velocity in hemodialysis patients

• Published in: Journal of Japanese Society for Dialysis Therapy Vol. 22; no. 2; pp. 157 - 161
• Main Authors: Imamura, Atsusi, Tanaka, Tamio, Harada, Takasi, Hara, Kohei, Taura, Koichi, Kitayama, Tosio, Yasumori, Ryokichi, Suyama, Hiroyuki, Yosio, Yukiharu
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Dialysis Therapy 1989
• ISSN: 0911-5889; 1884-6211; 1884-6211
• DOI: 10.4009/jsdt1985.22.157

Atherosclerotic change is a very important complication in hemodialysis patients. We therefore measured aortic pulse wave velocity (PWV) in hemodialysis patlents and studied the relationship between PWV and the risk factors for a therosclerosis. PWV was measured just after hemodialysis in each patient by MCG-400 (Fukuda). The subjects consisted of 14 patient with diabetes mellitus (DM group, mean age 58.6y) and 57 cases without diabetes mellitus (non-DM group, mean age 56.0y). The average duration of hemodialysis was 1.0 year in the DM group and 2.3 years in the non-DM group. The results were as follows: 1) PWV was significantly higher in the DM group (10.4m/sec) than the non-DM group (8.4m/sec). 2) In both groups, there was a positive correlation between age and PWV, and a negative correlation between the duration of hemodialysis and PWV. 3) There was a positive correlation between systolic blood pressure and PWV in the DM group, but none in the non-DM group. 4) In the DM group, there were negative correlations between PWV and LDL, VLDL, apo B, apo E and LCAT, but there were no correlations in the non-DM group. In conclusion, the PWV of the DM group seemed to be high, especially in patients with advanced, hypertension, poor-nourishment or in the early stage of hemodialysis.