Inhibition of leukotriene B4 formation in human polymorphonuclear leukocytes by halothane

The effect of halothane (2-bromo-2-chloro-1, 1, 1-trifluoroethane), an inhalation anesthetic, on the formation of leukotriene B4 (LTB4) was studied in human polymorphonuclear leukocytes stimulated with calcium ionophore A23187. Halothane inhibited the formation of LTB4 in a dose-dependent manner and...

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Bibliographic Details
Published inEnsho Vol. 6; no. 4; pp. 397 - 399
Main Authors Minakami, Shigeki, Takeshige, Koichiro, Yoshitake, Junichi, Sumimoto, Hideki, Yamaoka, Atsushi
Format Journal Article
LanguageJapanese
Published The Japanese Society of Inflammation and Regeneration 1986
Subjects
halothane
leukotriene B4
polymorphonuclear leukocyte
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ISSN0389-4290
1884-4006
1884-4006
DOI10.2492/jsir1981.6.397

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Summary:The effect of halothane (2-bromo-2-chloro-1, 1, 1-trifluoroethane), an inhalation anesthetic, on the formation of leukotriene B4 (LTB4) was studied in human polymorphonuclear leukocytes stimulated with calcium ionophore A23187. Halothane inhibited the formation of LTB4 in a dose-dependent manner and the inhibition was restored by the removal of halothane.
ISSN:0389-4290
1884-4006
1884-4006
DOI:10.2492/jsir1981.6.397