Separacene E, a New Tetraene Polyketide from the Marine Actinomycete, Streptomyces sp. SNJ210

The One Strain MAny Compounds (OSMAC) strategy resulted in discovery of a new tetraene mono-ol, separacene E (1), a new derivative of previously reported separacenes A-D from Streptomyces sp. SNJ210. The chemical structure of 1 was determined by NMR, mass, UV spectroscopy, and specific rotation calc...

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Bibliographic Details
Published inNatural product sciences Vol. 31; no. 2; pp. 148 - 152
Main Authors Lee, Jungro, Shin, Yoonho, Won, Tae Hyung, Bae, Munhyung
Format Journal Article
LanguageEnglish
Published 한국생약학회 30.06.2025
Subjects
약학
Online AccessGet full text
ISSN1226-3907
2288-9027
DOI10.20307/nps.2025.31.2.148

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Summary:The One Strain MAny Compounds (OSMAC) strategy resulted in discovery of a new tetraene mono-ol, separacene E (1), a new derivative of previously reported separacenes A-D from Streptomyces sp. SNJ210. The chemical structure of 1 was determined by NMR, mass, UV spectroscopy, and specific rotation calculations. Separacene E (1) possesses a methylated tetraene moiety along with a terminal carboxyl group, whereas separacenes A–D bear polyene polyol substructures. Separacene E (1) displayed moderate cytotoxicity against cancer cell line. KCI Citation Count: 0
ISSN:1226-3907
2288-9027
DOI:10.20307/nps.2025.31.2.148