Heat Shock Protein 70 Gene Polymorphisms in Han Nationality of China with Chronic Obstructive Pulmonary Diseases

• Published in: Current medical science Vol. 24; no. 1; pp. 28 - 31
• Main Author: 谢俊刚 徐永键 张珍祥 倪望 陈仕新
• Format: Journal Article
• Language: English
• Published: China Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 2004
• Subjects: China - ethnology; Ethnicity; Genetic Predisposition to Disease - genetics; HSP70 Heat-Shock Proteins - genetics; Humans; Polymorphism, Restriction Fragment Length; Pulmonary Disease, Chronic Obstructive - genetics; Smoking; 基因多态性; 慢性阻塞性肺疾病; 汉族人群; 热休克蛋白70; 遗传易感性; China; heat shock protein 70; lung disease,obstructive; smoking
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/BF02830699

In order to investigate whether polymorphism in gene for heat shock protein 70 (HSP70) has any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease(COPD), the geotypes of 88 patients with COPD and 87 healthy smoking control subjects were tested by polymerase chain reaction followed by restriction fragment polymorphism analysis for HSP70 gene. In COPD group, HSP70-1 genotype A/A, A/B and B/B was 59.1%, 35.2% and 5.7%, HSP70-2 genotype A/A, A/B and B/B was 26.1%, 54.6% and 19.3%, and HSP70horn genotype A/A, A/B and B/B was 70.4%, 27.3% and 2.3% respectively. In the control group, it was 60.9%, 27.5% and 3.5%, 20.7%, 56.3% and 23.0%, and 54.0%, 42.5and 3.5%, respectively. The frequency of polymorphic genetypes showed no difference between the COPD group and the control group (P>0.05). It was suggested that geneic polymorphism in HSP70 is not associated with development of COPD in Han nationality of China.