BLOOD TRANSFUSION AND COMPLEMENT SYSTEM

• Published in: Nihon Rinshō Masui Gakkai shi Vol. 4; no. 3; pp. 276 - 283
• Main Authors: IKEDA, Yasuaki, OKITA, Yasuharu, IKEDA, Kazumi, MAKINO, Yoshifumi, MARUYAMA, Shinji, MIYAKE, You, SUZUKI, Takakazu
• Format: Journal Article
• Language: English
• Published: THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA 1984
• ISSN: 0285-4945; 1349-9149
• DOI: 10.2199/jjsca.4.276

Introduction: Cmplement system is now the area of interest for those concerned with anesthesia on the patient's immunity. We examined the effect of blood and transfusion on complement system pre, during, (pre, after, blood transfusion) and after the operation. Subjects. The subjects of this study include 55 patients, who underwent elective surgery were categorized into four (4) groups according to the following criteria. Group 1: Blood loss less than 10% circulating blood flow (CBF) Group 2: Blood loss less than 20% CBF Group 3: Blood loss less than 30% CBF Group 4: Blood loss more than 30% CBF Measurements and Methods: 1. vital sign: MAP PR Hb Ht: 2. CH50 (Mayer's method) ACH 50 (Anano's method) C1q, C4, C3, C5, C9, Clinactivator, Factor B (single radial immunodiffusion method) 3. Albumin BCG method Results and Discussion We corrected our results with albumin levels since the dilution of blood by the infusion of fluid. Only C3 component has declined in every Groups, significicant changes in G3, G4, . Another measurements have no significant change in every groups. Authors propose three possible explanation to this phenomenon. (1) dilution of C3, (2) enhancement of C3 turnover, (3) decreased C3 supply due to macrophage dysfunction.