A Systematic Review: Antihyperglycemic Properties of Catharanthus roseus Linn

• Published in: Journal of young pharmacists Vol. 17; no. 1; pp. 62 - 69
• Main Authors: Dudhat, Keyur, Wanjari, Anita, Doelakeh, Elijah Skarlus
• Format: Journal Article
• Language: English
• Published: Bangalore InPharm 01.01.2025
• Subjects: Antidiabetics; Diabetes
• ISSN: 0975-1483; 0975-1505
• DOI: 10.5530/jyp.20251394

BackgroundDiabetes mellitus is a term for several diseases that affect how your body regulates blood sugar. Ayurveda has long used Catharanthus roseus Linn., to cure diabetes. This review aims to summarise existing scientific studies investigating this plant’s potential to manage diabetes.MethodologyThe review concentrated on current, significant research that was discovered using academic databases such as PubMed, SpringerLink, Web of Science and Google Scholar and that addressed the antihyperglycemic and antidiabetic effects of C. roseus. Only English research articles from January 2001 to May 2024 were included in the analysis.ResultsAfter reviewing 192 publications from January 2001 to May 2024, this article focus to 15 research studies on the effects of C. roseus on blood sugar regulation and diabetes management.ConclusionInterestingly, all the studies concurred that C. roseus appeared to have blood sugar-lowering effects in the test subjects. This potential antidiabetic benefit may be due to the plant’s ability to Increase insulin production from previously impaired beta cells in response to glucose and enhance the activity of genes involved in sugar uptake (GLUT-2 and GLUT-4).