The relationship of complete blood parameters, high-density lipoprotein cholesterol, and bilirubin values with disease severity in obstructive sleep apnea syndrome

• Published in: Türk nöroloji dergisi Vol. 30; no. 1; pp. 10 - 15
• Main Authors: Kılıçparlar Cengiz, Emine, Ekmekyapar Fırat, Yasemin, Neyal, Abdurrahman, Münife Neyal, Ayşe
• Format: Journal Article
• Language: English
• Published: Ankara Galenos Publishing House 2024
• Subjects: High density lipoprotein; Lipoproteins; Lymphocytes; Sleep apnea
• ISSN: 1309-2545; 1301-062X; 1309-2545
• DOI: 10.55697/tnd.2024.84

Objectives: This study aimed to compare total bilirubin levels with monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients diagnosed with obstructive sleep apnea syndrome (OSAS) according to the apnea-hypopnea index (AHI) values. Patients and methods: The files of patients who underwent polysomnography and had total bilirubin and complete blood count values were retrospectively reviewed. Patients were divided into three groups: AHI <5, AHI =5-29.99, and AHI ≥30. All blood parameters and calculated ratios were compared between the groups, and the relationship between these parameters and OSAS severity was investigated. Results: The study included 240 patients (149 males, 91 females; mean age: 47.4±11.9 years; range, 21 to 82 years). High-density lipoprotein values were significantly lower and MHR was significantly higher in the group with AHI ≥30 compared to the other two groups (p<0.001 and p=0.001, respectively). Apnea-hypopnea index was correlated with MHR (r=0.270, p<0.001). The groups were similar in terms of MLR, NLR, PLR, and total bilirubin levels. Conclusion: Considering that these easily accessible blood parameters are affected by many factors, they can only be used as auxiliary parameters in assessing the severity and follow-up of diseases such as OSAS.