The role of the interatrial shunt device in the treatment of patients with heart failure with preserved ejection fraction: experience from the REDUCE LAP-HF studies

• Published in: Kosin Medical Journal (Online) Vol. 40; no. 2; pp. 88 - 95
• Main Author: Kim, Bong-Joon
• Format: Journal Article
• Language: English
• Published: Kosin University College of Medicine 01.06.2025; 고신대학교 의과대학 학술지
• Subjects: atrial pressure; heart failure; interatrial shunt device; 의학일반
• ISSN: 2005-9531; 2586-7024
• DOI: 10.7180/kmj.24.150

Heart failure with preserved ejection fraction (HFpEF) is characterized by increased left ventricular filling pressure and elevated left atrial pressure. Despite advances in medical treatments, the management of HFpEF patients is often challenging due to multiple comorbidities, leading to polypharmacy and associated side effects. Consequently, there is an increasing demand for procedural or device-based therapies in HFpEF management. Over the past decade, the transcatheter interatrial shunt device (IASD), designed to create a passage between the left atrium and the right atrium, has emerged as a novel therapeutic option. The IASD offers potential benefits by reducing left atrial pressure at rest and during exercise. The efficacy and safety of the IASD were demonstrated in the REDUCE LAP-HF (Reduce Left Atrial Pressure in Patients with Heart Failure) study series. Furthermore, IASD has been shown to support positive cardiac remodeling. With the availability of more data, appropriate indications for the use of IASDs are becoming more evident, and criteria for patient selection in future studies are needed.