SIGNAL MECHANISM OF INHIBITION OF BIFIDOBACTERIA ON GROWTH OF COLON CANCER

• Published in: Chinese journal of cancer research Vol. 17; no. 2; pp. 145 - 149
• Main Author: 戴建宜 王立生 朱惠明 潘令嘉 马晓东 张亚历 周殿元
• Format: Journal Article
• Language: English
• Published: Department of Gastroenterology, Shenzhen Municipal People's Hospital, Shenzhen 518020%Department of Gastroenterology, Nanfang Hospital, Guangzhou 510515 01.06.2005
• Subjects: 信号机制; 病理机制; 细菌感染; 结肠癌; Extracellular signal- regulated protein kinase; Signal transduction; Colon cancer; Bifidobacteria; C-jun N-terminal kinase; NF-kB
• ISSN: 1000-9604; 1993-0631
• DOI: 10.1007/s11670-005-0061-y

Objective: To explore the antitumor mechanisms of bifidobacteria adolescence in vivo. Methods: The content of extracellular signal regulated proteins (ERK)1/2, C-Jun N-terminal kinase (JNK), p38, c-fos and c-jun in nude mouse transplanted large bowel carcinoma was detected by using laser confocal microscopy. The expression of NF-κB was determined by immunohistochemistry. Results: After the nude mouse transplanted tumor was treated with bifidobacteria, the average fluorescent strength of ERK1/2, JNK, c-fos and c-jun was significantly lower than that in tumor control group (P<0.01). The average fluorescent strength of p38 was not obvious difference in the two groups (P>0.05). The positive cell density of NF-κB in large bowel carcinoma transplantation tumors in Bifidobacterium injection group was markedly lower than that in tumor group(P<0.01). Conclusion: bifidobacteria adolescence could markedly decrease the activity of ERK1/2 and JNK, the expression c-fos and c-jun, and the activity of NF-κB.