Pyoderma gangrenosum: update and guidance

• Published in: Revista Brasileira de cirurgia plástica Vol. 37; no. 4; pp. 423 - 430
• Main Authors: Vieira, Luiz Felipe Duarte Fernandes, Almeida, Carlos Lacerda Andrade, Souza, Alexandre Wagner de, Rêgo, Jozelia, Vale, Everton Siviero do, Pegas, Jose Roberto Pereira
• Format: Journal Article
• Language: English
• Published: Thieme Revinter Publicações Ltda 01.12.2022
• Subjects: autoimmunity; medical; neutrophils; pyoderma; pyoderma gangrenosum; skin diseases; societies
• ISSN: 2177-1235; 1983-5175; 2177-1235
• DOI: 10.5935/2177-1235.2022RBCP.671-en

Introduction: The pyoderma gangrenosum (PG) is a neutrophilic disease, rare but with a poor outcome. The Capitulum of Wound treatment of the Brazilian Society of Plastic Surgery (SBCP) promoted a discussion with the Brazilian societies of Dermatology and Rheumatology to extract the best procedures in diagnostic and treatment. Methods: Broad review of published articles related to the subject and compilation of guidelines of diagnostic and treatment by two advisors of each involved society, plastic surgery, dermatology and rheumatology. Results: The PG is not an exclusion disease anymore, with well defined criteria for its diagnostic and literature based treatment, refined by the authors, including the use of biological therapies. Conclusion: The PG remains challenging, but systematizing the investigation and the use of new drugs has opened a new horizon of treatments, interfering in the pathophysiology in a positive manner with fewer side effects than immunosuppressive therapy alone.