IMMUNE TOLERANCE INDUCED BY GAMMA－RAY IRRADIATION

Objective: To detect the existence of immune tolerance induced by gamma-ray irradiation. Methods:Peritoneal cells were harvested from mice subjected to 5 Gy ^60Co gamma-ray total body irradiation at 3d, 7d, 15d and 30d, then their counts, morphological changes and IL-12 gene expression were investig...

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Published inChinese journal of cancer research Vol. 15; no. 2; pp. 121 - 123
Main Author 练燕 王延江 粟永萍 冉新泽 艾国平 刘晓宏 郭朝华 程天民
Format Journal Article
LanguageEnglish
Published Department of Hematology & Oncology, Southwest Hospital%Institute of Combined Injury, Third Military Medical University, Chongqing 400038 01.06.2003
Subjects
伽玛刀
免疫耐受性
树突状细胞
白细胞介素－12
Irradiation
Dendritic cell
Peritoneal lavage cell
Interleukin 12
Immune tolerance
Morphology
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ISSN1000-9604
1993-0631
DOI10.1007/BF02974914

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Summary:Objective: To detect the existence of immune tolerance induced by gamma-ray irradiation. Methods:Peritoneal cells were harvested from mice subjected to 5 Gy ^60Co gamma-ray total body irradiation at 3d, 7d, 15d and 30d, then their counts, morphological changes and IL-12 gene expression were investigated. Results: After irradiation, the peritoneal cells were sharply reduced,the cell morphology shifted from round-like to polymorphic and fusiform with some processes,expression of IL-12 p35 was seriously suppressed, while that of IL-12 p40 greatly enhanced. Conclusion: Our data highly suggest that the gamma-ray irradiation could potentially induce dendritic cell (DC) commitment and immune tolerance.
Bibliography:11-2591/R
R815
ISSN:1000-9604
1993-0631
DOI:10.1007/BF02974914