REPORT ON THREE CASES WITH ANTI-Bg-a ANTIBODY CROSS-REACTING WITH HLA ANTIGENS

• Published in: Journal of the Japan Society of Blood Transfusion Vol. 38; no. 3; pp. 458 - 462
• Main Authors: Matsuzaki, Tatsunori, Ishida, Tomoko, Okubo, Susumu, Yasunaga, Kojiro, Ohnishi, Shuji, Miyamoto, Atsuko
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Transfusion Medicine and Cell Therapy 1992
• ISSN: 0546-1448; 1883-8383
• DOI: 10.3925/jjtc1958.38.458

Here reported are antibodies of IgG type found in two pregnant women and in another patient of myelodysplastic syndrome (MDS), which reacted to Bg (a+) red cells but not to Bg (a-) nor their own red cells. Their red blood groups were all Bg (a-). Moreover, the LCT-AHG test revealed that these antibodies cross-reacted to HLA B7-, Bw60- or 61-positive lymphocytes. Absorption of the sera by the platelets having these HLA antigens deprived them of their reactivity against Bg (a+) red cells. The anti-Bg-a of the two pregnant women who had never received blood transfusion seemed to be caused by past HLA-antigen incompatible pregnancy between mother and baby. However, the neonates showed no hemolytic disease (HDN) nor laboratory abnormalities. The anti-Bg-a in the MDS patient, which disappeared after 6 months, seemed to have been caused by frequent red cells (CRC) and platelet (PC) transfusions. In this patient, transfusion of PC-HLA was proved to be more effective than that of random PC. The anti-Bg-a antibody seems scarecely cause troubles in red cell transfusion or in pregnancy. However, as anti-HLA may cause ineffectiveness or adverse reaction against transfusion of such lymphocyte-rich blood component as PC, PC-HLA may be preferable for the patients with anti-Bg-a.