Association of a Single Nucleotide Polymorphism (SNP) in Porcine MYC Gene with Economic Traits in Pigs

• Published in: Journal of Agriculture & Life Science Vol. 48; no. 2; pp. 111 - 121
• Main Authors: Oh, Jae-Don, Song, Ki-Duk, Caccho, Roxan Grace, Seong, Jiyeon, Choi, Eun-Ji, Yu, Myungsang, Kim, Kyoungtae, Kim, Tae-Hun, Kim, Sung-Hoon, Kim, Eui-Soo, Lee, Hak-Kyo, Kong, Hong-Sik
• Format: Journal Article
• Language: English
• Published: 경상국립대학교 농업생명과학연구원 30.04.2014; 농업생명과학연구원
• Subjects: 자연과학일반; Economic trait; PCR-RFLP; Single nucleotide polymorphism; Body weight; MYC
• ISSN: 1598-5504; 2383-8272
• DOI: 10.14397/jals.2014.48.2.111

MYC (v-myelocytomatosis viral oncogene homologue) is a regulator gene that encodes for a nuclear phosphoprotein. Porcine MYC gene was mapped on chromosome SSC 4p13 and is associated with a variety of functions such as cell proliferation and cell growth. MYC expression is coupled to a multitude of physiological processes and is regulated by hormones, growth factors, cytokines, lymphokines, nutritional status, development and differentiation. MYC is also involved in myogenesis, muscle hyperplasia and adipogenesis. In this study, we investigated SNPs in MYC gene and their association with economic traits in Duroc, Landrace and Yorkshire populations. We detected a single point mutation in exon 3 of porcine MYC gene as a change of T to C at 906 base (amino acid position 302, nonsynomous mutation of alanine) in MYC-N domain. MYC mutation (T906C) was significantly associated with age at 90 kg in these breeds, signifying that this mutation can serve as a selection marker for growth traits in pigs.