Short-term and long-term effects in vascular endothelium of exercise for patients with end stage renal disease

• Published in: Annals of physical and rehabilitation medicine Vol. 61; pp. e294 - e295
• Main Authors: Miura, M., Hirayama, Hirayama, Y., Nishida, A., Ishizuka, K., Kinoshita, H., Ito, O., Kohzuki, M.
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.07.2018
• ISSN: 1877-0657; 1877-0665
• DOI: 10.1016/j.rehab.2018.05.689

Endothelial dysfunction occurs in chronic kidney disease (CKD) and increases the risk for cardiovascular disease. The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression. In the present study, we investigate short-term and long-term effects of the vascular endothelium of intra-dialytic exercise for patients with end stage renal disease. Total 15 of subjects, included seven patients (32–89 years) with CKD and eight healthy adults participated in this study. The subjects were exercised handgrip training for the 2weeks home-based training program consisted of 7 daily handgrip session of 12minutes each at the Borg rating of perceived exertion (RPE) for 11–13. The primary outcome was peripheral endothelial function. Secondary outcomes were physical function and biochemical tests such as cholesterol, IL6 and TNF-alpha. After the first intervention as the short-term effects, the patients in CKD group and healthy adults had significant improvement in peripheral endothelial function (P<0.05) from before the intervention, but not in grip strength. Conversely, 2 weeks after the intervention as the long-term effects, peripheral endothelial function and grip strength have been improved significantly only in CKD group (P<0.05). In this study, the safety and efficacy of conventional handgrip training were confirmed without a sudden drop of blood pressure or any other side effects. Exercise training for handgrip is very convenient, has the potential to improve endothelial dysfunction. These results indicate that the exercise for handgrip training may improve the patient's condition equally to the lower limb exercise.