ISPOL'ZOVANIE PREPARATOV KAL'TsIYa I VITAMINA D V KOMPLEKSE S ADEKVATNYM OSTEOSINTEZOM PRI PSEVDOARTROZAKh KOSTEY GOLENI

• Published in: Osteoporoz i osteopatii Vol. 14; no. 3; pp. 25 - 27
• Main Authors: GYuL'NAZAROVA, V, RODIONOVA, S S, KUZNETsOVA, O A, ZEL'SKIY, I A, PEN'KOV, M Yu
• Format: Journal Article
• Language: English
• Published: Endocrinology Research Centre 15.12.2011
• Subjects: иммобилизационный остеопороз; Кальций-Д Никомед; комбинированное лечение; осте-синтез; псевдоартрозы нижних конечностей
• ISSN: 2072-2680; 2311-0716; 2311-0716
• DOI: 10.14341/osteo2011325-27

Expediency of the application of adequate osteosynthesis in combination with Ca + vitamin D intake for the treatment of pseudarthrosis (PA) complicated by regional immobilization osteoporosis was proved by the results of comparative study (treatment group - 23, control group - 33 subjects). Reliable decrease in time of consolidation by 15.3% was noted in treatment group as compared to controls. That decrease resulted from the transition of “lazy bone ” state typical for regional immobilization to a more active state of bone remodeling. Activization of remodeling process on with intake of Ca D3 Nycomed was proved by sigificant increase in the activity level of alkaline phosphatase and its isoenzyme acid phosphatase. Predominance of osteogenesis process over resorption in the early postoperative period was demonstrated by significant (p=0.004) increase in phosphatase index in the treatment group within first three months after operation as compared to the control group.