Expression patterns of Rho-associated protein kinase signaling pathway-related genes in mouse submandibular glands

Salivary glands are exocrine glands that secrete saliva into the oral cavity, and secreted saliva plays essential roles in oral health. Therefore, maintaining the salivary glands in an intact state is required for proper production and secretion of saliva. To investigate a specific signaling pathway...

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Bibliographic Details
Published inInternational journal of oral biology Vol. 46; no. 2; pp. 81 - 84
Main Authors Kim, Ki-Chul, Roh, Sangho
Format Journal Article
LanguageEnglish
Published 대한구강생물학회 30.06.2021
Subjects
치의학
RNA sequencing
ROCK signaling pathway
Submandibular glands
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ISSN1226-7155
2287-6618
DOI10.11620/IJOB.2021.46.2.81

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Summary:Salivary glands are exocrine glands that secrete saliva into the oral cavity, and secreted saliva plays essential roles in oral health. Therefore, maintaining the salivary glands in an intact state is required for proper production and secretion of saliva. To investigate a specific signaling pathway that might affect the maintenance of mouse submandibular gland (SMGs), RNA sequencing was performed. In SMGs, downregulated expression patterns of Rho-associated protein kinase (ROCK) signaling pathway-related genes, including Rhoa, Rhob, Rhoc, Rock1, and Rock2, were observed. Gene expression profiling analyses of these genes indicate that the ROCK signaling pathway is a potential signal for SMG maintenance.
ISSN:1226-7155
2287-6618
DOI:10.11620/IJOB.2021.46.2.81