A micro review on the role of recently emerged Artificial Intelligence (AI) tools and algorithms in microbiome-gut-brain-axis associated disease therapy via psychobiotics

The microbiome-gut-brain axis involves the bidirectional connection between the gastrointestinal tract, gut microbiome, and central nervous system, and it is pivotal for mental well-being. Imbalances in the gut microbiome (dysbiosis) can disrupt neurotransmitter synthesis, leading to neurodegenerati...

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Bibliographic Details
Published inPrecision Medication Vol. 2; no. 3; p. 100039
Main Author Lim, Leonard Whye Kit
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2025
Subjects
Artificial intelligence
Disease
Microbiome-gut-brain axis
Psychobiotics
Therapy
Therapy
Psychobiotics
Disease
Artificial intelligence
Microbiome-gut-brain axis
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ISSN2950-5232
DOI10.1016/j.prmedi.2025.100039

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Summary:The microbiome-gut-brain axis involves the bidirectional connection between the gastrointestinal tract, gut microbiome, and central nervous system, and it is pivotal for mental well-being. Imbalances in the gut microbiome (dysbiosis) can disrupt neurotransmitter synthesis, leading to neurodegenerative diseases. Recent researches highlight psychobiotics as effective treatments for mental health conditions like depression. With advancements in artificial intelligence (AI) and large datasets, psychobiotic research has accelerated. AI tools are increasingly used for the prediction, identification, and diagnosis of gut microbiome compositions, enabling faster and more accurate discovery of therapeutic candidates. This review explores the role of AI in enhancing microbiome-gut-brain-axis-related disease therapies through psychobiotics and discusses future directions for this rapidly evolving research field.
ISSN:2950-5232
DOI:10.1016/j.prmedi.2025.100039