CCNE1 EXPRESSION AND CA-125 LEVELS IN HIGH GRADE SEROUS CARCINOMA OVARY AT MOHAMMAD HOESIN HOSPITAL PALEMBANG ; A SINGLE-INSTITUTION DESCRIPTIVE STUDY

High grade serous carcinoma (HGSC) of the ovary is the dominant subtype causing death from ovarian cancer. CCNE1 amplification occurs in 20% of ovarian HGSC and is associated with recurrence after platinum chemotherapy. Assessment of CCNE1 expression can be a screening for CCNE1 amplification. Measu...

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Published inJurnal Kedokteran Kesehatan Universitas Sriwijaya Vol. 12; no. 2; pp. 257 - 266
Main Authors Fitriani, Dianli, Wresnindyatsih, Susilawati
Format Journal Article
LanguageEnglish
Indonesian
Published Universitas Sriwijaya 30.04.2025
Subjects
ca-125
ccne1 expression
hgsc
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ISSN2406-7431
2614-0411
DOI10.32539/jkk.v12i2.671

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Summary:High grade serous carcinoma (HGSC) of the ovary is the dominant subtype causing death from ovarian cancer. CCNE1 amplification occurs in 20% of ovarian HGSC and is associated with recurrence after platinum chemotherapy. Assessment of CCNE1 expression can be a screening for CCNE1 amplification. Measurement of CA-125 levels is routinely used for treatment monitoring and recurrence of HGSC patients. This study aims to assess CCNE1 expression, demographic characteristics and CA-125 levels of ovarian HGSC patients. Of the 31 HGSC patients, the study subjects were dominated by patients aged >50 years (61.3%), clinical stage FIGO III (64.5%), CCNE1 overexpression (71%), preoperative CA-125 levels ≥500 U/ml (77.4%) and postchemotherapy CA-125 levels <35 U/ml (58.1%).
ISSN:2406-7431
2614-0411
DOI:10.32539/jkk.v12i2.671