The effect of Sclerosing drugs on the Tunica albuginea (Experimental study)

• Published in: Research journal of pharmacy and technology Vol. 17; no. 6; pp. 2846 - 2854
• Main Authors: Kuneshov, Kozhakhmet, Seidinov, Shora, Tulezhanov, Nurpeis, Tеmurov, Fazladin, Massadikov, Shkurulla
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 25.06.2024
• Subjects: Alcohol; Animals; Biomedical research; Disease; Drug dosages; Ethanol; Membranes; Pharmaceuticals; Physiology; Proteins; Rabbits; Sclerotherapy; Sperm; Spermatogenesis; Toxicity
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.52711/0974-360X.2024.00447

Background: The relevance of the stated research subject is determined by the need to conduct an experimental study of the effects of various dosages of sclerosing drugs, such as aethoxysklerol, kanamycin, 70% ethyl alcohol on the general condition of the tissues of the Tunica albuginea. The main purpose of this research is to analyse the degree of influence exerted by sclerosing drugs on the Tunica albuginea when conducting studies using rabbits, as the only laboratory rodents with which it is possible to obtain recombinant pharmaceutical proteins, conduct oral studies, or inject dosage forms into the stomach without violating the integrity of the tablets. Materials and Methods: The leading approach in this research is a practical study performed on 19 rabbits aged 7-8 months, with their division according to the principle of analogues into several main groups (three rabbits in each of them and one rabbit separately) with the introduction of the experimental data obtained in special tables. Results: The results obtained in this research indicate that there are considerable prospects for studying the effect of sclerosing drugs on the Tunica albuginea, from the standpoint of the practical application of the data obtained during the experiment for the treatment of a number of serious diseases in stationary conditions. Conclusion: The study results and the conclusions formulated on their basis have a practical value from the standpoint of obtaining the necessary evidence of the safety of advanced sclerotherapy, which is: improvement of hemodynamic parameters of the testicular parenchyma, the complete absence of structural changes in its tissues and the epididymis in conditions of preserving the full course of spermatogenesis.