Establishment of Sister Chromatid Cohesion During Chromosome Replication

In every round of cell division, two newly duplicated sister chromatids are held together by the ring-shaped cohesin complex to ensure faithful inheritance of chromosomes in dividing cells. The cohesin complex mediates sister chromatid cohesion by topologically entrapping two replicated DNAs within...

Full description

Saved in:
Bibliographic Details
Published inSeibutsu Butsuri Vol. 65; no. 3; pp. 129 - 134
Main Author MURAYAMA, Yasuto
Format Journal Article
LanguageEnglish
Japanese
Published The Biophysical Society of Japan General Incorporated Association 2025
Subjects
biochemistry
chromosome segregation
cohesin complex
DNA replication
sister chromatid cohesion
Online AccessGet full text
ISSN0582-4052
1347-4219
DOI10.2142/biophys.65.129

Cover

More Information
Summary:In every round of cell division, two newly duplicated sister chromatids are held together by the ring-shaped cohesin complex to ensure faithful inheritance of chromosomes in dividing cells. The cohesin complex mediates sister chromatid cohesion by topologically entrapping two replicated DNAs within the ring cavity. Recent studies with purified cohesin have begun to reveal the biochemical properties that control chromosome organisation. This review summarises these biochemical studies and discusses how cohesin associates with DNA and establishes sister chromatid cohesion.
ISSN:0582-4052
1347-4219
DOI:10.2142/biophys.65.129