In vitro Degradation Study of a Braided Thin-Walled Biodegradable Ureteral Stent

The main disadvantage of conventional ureteral stents commonly used to provide urinary drainage after urological practice is that the patients have to undergo a secondary surgical procedure to remove stents. A new braided thin-walled biodegradable ureteral stent composed of PGA （ polyglycolic acid）...

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Published in东华大学学报（英文版） Vol. 29; no. 5; pp. 385 - 388
Main Author 尚亚峰 邹婷 张明庆 王富军 周君梅 王文祖 谢华 王璐 陈方
Format Journal Article
LanguageEnglish
Published Department of Urology, Shanghai Children's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200040, China%Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China 2012
Subjects
外科学
外科诊疗器
病理学
诊断学
thin-walled
PLGA (copolymer of polylactic and polyglycolic acid)
PGA (polyglycolic acid)
braided
mechanical property
degradable ureteral stent
in vitro degradation
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ISSN1672-5220

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Summary:The main disadvantage of conventional ureteral stents commonly used to provide urinary drainage after urological practice is that the patients have to undergo a secondary surgical procedure to remove stents. A new braided thin-walled biodegradable ureteral stent composed of PGA （ polyglycolic acid） and PLGA （ eopolymer of polylactic and polygiycolic acid） mnltifilaments was evaluated in v/tro in this study. In vitro degradation was performed in artificial urine with pH of 5.8 and the temperature of 37~C. The mass loss, mechanical properties, and morphology were observed at different degradaing time intervals of 0, 1, 2, 3, 4, and 5 weeks. The stent had a thinner wail than those of other degradable stents and provided better mechanical properties. The braided thin-walled biodegradable ureteral stents began to degrade after 2 weeks. At the week of 5, the stents were fully degraded. The degradative process of stents is smooth and well controlled.
Bibliography:31-1920/N
braided; thin-walled; degradable ureteral stent; PGA（polyglycolic acid） ; PLGA （ copolymer of polylactic and polyglycolicacid） ; in vitro degradation; mechanical property
SHANG Ya-feng,ZOU Ting,ZHANG Ming-qing,WANG Fu-jun,ZHOU Jun-mei,WANG Wen-zu,XIE Hua,WANG Lu,CHEN Fang（1 Department of Urology, Shanghai Children＇s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200040, China; 2 Key Laboratory of Textile Science ＆ Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China）
The main disadvantage of conventional ureteral stents commonly used to provide urinary drainage after urological practice is that the patients have to undergo a secondary surgical procedure to remove stents. A new braided thin-walled biodegradable ureteral stent composed of PGA （ polyglycolic acid） and PLGA （ eopolymer of polylactic and polygiycolic acid） mnltifilaments was evaluated in v/tro in this study. In vitro degradation was performed in artificial urine with pH of 5.8 and the temperature of 37~C. The mass loss, mechanical properties, and morphology were observed at different degradaing time intervals of 0, 1, 2, 3, 4, and 5 weeks. The stent had a thinner wail than those of other degradable stents and provided better mechanical properties. The braided thin-walled biodegradable ureteral stents began to degrade after 2 weeks. At the week of 5, the stents were fully degraded. The degradative process of stents is smooth and well controlled.
ISSN:1672-5220