Endometrial flushing α V β 3 integrin, glycodelin and PGF2α levels for evaluating endometrial receptivity in women with polycystic ovary syndrome, myoma uteri and endometrioma

• Published in: Gynecological endocrinology Vol. 33; no. 9; pp. 716 - 720
• Main Authors: Demir, Mustafa, Ince, Onur, Ozkan, Bulent, Kelekci, Sefa, Sutcu, Recep, Yilmaz, Bulent
• Format: Journal Article
• Language: English
• Published: England 02.09.2017
• Subjects: Adult; Body Fluids - metabolism; Cross-Sectional Studies; Dinoprost - metabolism; Endometriosis - metabolism; Endometrium - metabolism; Female; Glycodelin - metabolism; Humans; Integrin alphaVbeta3 - metabolism; Leiomyoma - metabolism; Polycystic Ovary Syndrome - metabolism; Uterine Neoplasms - metabolism; Young Adult; endometrial flushing fluid; endometrial receptivity; myoma uteri; Endometrioma; PGF2α; glycodelin; polycystic ovary syndrome; αVβ3 integrin
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590.2017.1318276

The aim of this cross-sectional study is to compare endometrial flushing fluid levels of α β integrin, glycodelin and PGF2α during the midluteal phase of the menstrual cycle of women with polycystic ovary syndrome (PCOS, n = 20), myoma uteri (n = 20) and endometrioma (n = 19) with the healthy controls (n = 20). After collecting samples at the midluteal phase of ovulatory volunteers and storing them at -80 °C, α β integrin, glycodelin and PGF2α levels were analyzed using ELISA. The mean ages of the groups were 28.90 ± 5.45, 37.25 ± 2.73, 32.84 ± 6.62 and 32.15 ± 5.18 in PCOS, myoma uteri, endometrioma and control groups, respectively. The α β integrin level (ng/ml) was statistically significantly higher in endometrioma group (9.70 ± 1.72, p < 0.05) as compared to myoma uteri and control groups. Similarly, glycodelin level (ng/ml) was significantly higher in endometrioma group (341.04 ± 93.32) than PCOS (p < 0.01), myoma uteri (p < 0.001) and healthy subjects (p < 0.001). Moreover, PGF2α level (350.04 ± 464.50 ng/ml) was significantly higher in PCOS group relative to myoma uteri (p < 0.001), endometrioma (p < 0.05) and control (p < 0.05) groups. In conclusion, α β integrin level was significantly higher in endometrioma subjects than those with myoma uteri and control groups; glycodelin level was significantly higher in endometrioma group than other three groups, and lastly, PCOS patients had significantly higher PGF2α levels than those patients with myoma uteri, endometrioma and controls.