纳秒脉冲电场肿瘤电消融的分子生物学机制

近年来，纳秒脉冲技术的临床应用研究不断深入与发展，但是其治疗的细胞学机制至今仍未完全阐明。在学术界存在各种假说和理论。研究证实，纳秒脉冲电场可以穿透细胞膜形成纳米孔，引起钙离子内流；也可作用于细胞内膜，引起内质网损伤、线粒体膜电位差的改变；进一步还可以损伤细胞微丝骨架，导致细胞形态的变化。本文结合最新的研究进展，围绕纳秒脉冲电场对细胞膜和细胞器的分子作用机制进行介绍。...

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Published inZhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 44; no. 6; pp. 678 - 683
Main Author 岑超 陈新华 郑树森
Format Journal Article
LanguageChinese
English
Published 浙江大学附属第一医院肝胆胰外科,浙江杭州,310003 25.01.2015
Beijing Zhongke Journal Publising Co. Ltd
Subjects
激光
电离
电穿孔
细胞／辐射效应
综述
肿瘤／治疗
辐射
肿瘤/治疗
Radiation,ionizing
Neoplasms/therapy
激光
Lasers
细胞/辐射效应
Electroporation
Cells/radiation effects
综述
Review
电穿孔
辐射,电离
Online AccessGet full text
ISSN1008-9292
DOI10.3785/j.issn.1008-9292.2015.11.13

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Summary:近年来，纳秒脉冲技术的临床应用研究不断深入与发展，但是其治疗的细胞学机制至今仍未完全阐明。在学术界存在各种假说和理论。研究证实，纳秒脉冲电场可以穿透细胞膜形成纳米孔，引起钙离子内流；也可作用于细胞内膜，引起内质网损伤、线粒体膜电位差的改变；进一步还可以损伤细胞微丝骨架，导致细胞形态的变化。本文结合最新的研究进展，围绕纳秒脉冲电场对细胞膜和细胞器的分子作用机制进行介绍。
Bibliography:Nanosecond pulsed electric field ablation has been widely applied in clinical cancer treatment, while its molecular mechanism is still unclear. Researchers have revealed that nanosecond pulsed electric field generates nanopores in plasma membrane, leading to a rapid influx of Ca^2＋; it has specific effect on intracellular organelle membranes, resulting in endoplasmic reticulum injuries and mitochondrial membrane potential changes. In addition, it may also change cellular morphology through damage of cytoskeleton. This article reviews the recent research advances on the molecular mechanism of cell membrane and organelle changes induced by nanosecond pulsed electric field ablation.
33-1248/R
CEN Chao, CHEN Xin-hua, ZHENG Shu-sen （Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhefiang University School of Medicine, Hangzhou 310003, China）
Neoplasms/therapy ; Electroporation ; Radiation, ionizing; Lasers ;Cells/radiation effects; Review
cenchao07@163.com第一作者：岑超(1989-), 男, 博士研究生, 主要从事纳秒脉冲电场肿瘤电消融的作用机制研究; E-mail:; http://orcid.org/0000-0002-9738-7242
ISSN:1008-9292
DOI:10.3785/j.issn.1008-9292.2015.11.13