LACTOFERRIN – A MULTIVALENT MOLECULE

Lactoferrin (Lf) is an iron-chelating glycoprotein present in the whey protein fraction in the milk of the majority of mammals. Since identifying bovine Lf (bLf) 85 years ago, the interest in this molecule has grown significantly. Thus, apart from its iron-binding and related antioxidant mechanisms,...

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Published inRomanian archives of microbiology and immunology Vol. 83; no. 2; pp. 108 - 115
Main Authors Costea, Diana-Antonia, Lazăr, Veronica
Format Journal Article
LanguageEnglish
Published Bucharest Institutul Cantacuzino 30.06.2024
Subjects
Amino acids
Antioxidants
Apoptosis
Breast milk
Cell cycle
Chelation
Fetuses
Glycoproteins
Glycosylation
Histidine
Immune system
Immunity (Disease)
Immunoglobulins
Infants
Intestinal microflora
Iron
Lactoferrin
Metastases
Metastasis
Methionine
Microbiota
Microorganisms
Neutrophils
Oxidative stress
Pathogens
Proteins
Reactive oxygen species
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ISSN1222-3891
2601-9418
DOI10.54044/RAMI.2024.02.05

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Summary:Lactoferrin (Lf) is an iron-chelating glycoprotein present in the whey protein fraction in the milk of the majority of mammals. Since identifying bovine Lf (bLf) 85 years ago, the interest in this molecule has grown significantly. Thus, apart from its iron-binding and related antioxidant mechanisms, Lf was described as implicated in protecting the human organism by its immune-promoting, antimicrobial, and anti-carcinogenic mechanisms. Since the intrauterine period and throughout life, Lf ensures a balance between innate and adaptative immunity and can inhibit the growth of pathogenic microorganisms and tumor metastasis. This paper summarizes the aforementioned mechanisms of this multivalent molecule involved in innate immunity.
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ISSN:1222-3891
2601-9418
DOI:10.54044/RAMI.2024.02.05