Layered Double Hydroxide Modified by PEGylated Hyaluronic Acid as a Hybrid Nanocarrier for Targeted Drug Delivery

In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and pref- erable disease treatments. In this study, using 5-fluorouracil （5-FU）as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system （LDH/HA-PEG/5-FU）was conceived and...

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Published inTransactions of Tianjin University Vol. 22; no. 3; pp. 237 - 246
Main Author 董岸杰 李雪 王伟伟 韩尚聪 刘鉴锋 刘金剑 赵军强 许舒欣 邓联东
Format Journal Article
LanguageEnglish
Published Tianjin Tianjin University 01.06.2016
Subjects
5-氟尿嘧啶
Engineering
Humanities and Social Sciences
Mechanical Engineering
multidisciplinary
Science
层状双氢氧化物
有机-无机杂化
纳米载体
聚乙二醇化
药物输送
载体改性
透明质酸
targeted drug delivery
HA-PEG, intercalation/adsorption
controlled release
layered double hydroxide
HA-PEG,intercalation/adsorption
targeted drug deliv-ery
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ISSN1006-4982
1995-8196
DOI10.1007/s12209-016-2710-2

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Summary:In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and pref- erable disease treatments. In this study, using 5-fluorouracil （5-FU）as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system （LDH/HA-PEG/5-FU）was conceived and manufactured by the adsorption of PEGylated hyaluronic acid （HA-PEG）on the surface of layered double hydroxide （LDH, prepared via hydrothermal method） and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5- FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of pH- degradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed pH-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.
Bibliography:12-1248/T
In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and pref- erable disease treatments. In this study, using 5-fluorouracil （5-FU）as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system （LDH/HA-PEG/5-FU）was conceived and manufactured by the adsorption of PEGylated hyaluronic acid （HA-PEG）on the surface of layered double hydroxide （LDH, prepared via hydrothermal method） and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5- FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of pH- degradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed pH-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.
layered double hydroxide; HA-PEG, intercalation/adsorption; controlled release; targeted drug delivery
ISSN:1006-4982
1995-8196
DOI:10.1007/s12209-016-2710-2