Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry

• Published in: European journal of endocrinology Vol. 164; no. 6; pp. 877 - 884
• Main Authors: Fieffe, Sandrine, Morange, Isabelle, Petrossians, Patrick, Chanson, Philippe, Rohmer, Vincent, Cortet, Christine, Borson-Chazot, Françoise, Brue, Thierry, Delemer, Brigitte
• Format: Journal Article Web Resource
• Language: English
• Published: Bristol BioScientifica 01.06.2011; European Society of Endocrinology; Oxford Univ. Press
• Subjects: Acromegaly; Acromegaly - complications; Acromegaly - epidemiology; Acromegaly/complications/epidemiology; Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biological Markers; Biomarkers; Body Mass Index; Cancer; Child; Clinical Study; Databases, Factual; Diabetes Complications; Diabetes Complications - epidemiology; Diabetes. Impaired glucose tolerance; Disease Progression; Endocrine pancreas. Apud cells (diseases); Endocrinologie, métabolisme & nutrition; Endocrinology, metabolism & nutrition; Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Follow-Up Studies; France; France - epidemiology; Fundamental and applied biological sciences. Psychology; Human Growth Hormone; Human Growth Hormone - blood; Human health sciences; Humans; Hypertension; Hypertension - complications; Hypertension - epidemiology; Hypertension/complications/epidemiology; Hypothalamus. Hypophysis. Epiphysis (diseases); Insulin-Like Growth Factor I; Insulin-Like Growth Factor I - analysis; Life Sciences; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Multivariate Analysis; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pituitary Neoplasms; Pituitary Neoplasms - complications; Pituitary Neoplasms - epidemiology; Pituitary Neoplasms/complications/epidemiology; Registries; Risk Factors; Sciences de la santé humaine; Sex Ratio; Vertebrates: endocrinology; Young Adult; France; Europe; Endocrinopathy; French; Prevalence; Register; Diabetes mellitus; Pituitary diseases; Diseases of the osteoarticular system; Risk factor; Acromegaly; Evolution; Epidemiology; Endocrinology
• ISSN: 0804-4643; 1479-683X; 1479-683X
• DOI: 10.1530/EJE-10-1050

ObjectivesThe French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly.MethodsThis study has been conducted on all the patients recorded from 1999 until 2004 (519 patients). Evolution of cohorts' was reassessed in 2009. Of the different variables recorded in the registry: age, sex, body mass index (BMI), duration of acromegaly, GH, IGF1 and prolactin levels, pituitary tumor size, hormonal deficiencies, presence, duration and treatment of diabetes, hypertension, and rheumatological disease were analyzed.ResultsThe prevalence of diabetes in the registry was 22.3%. Diabetic patients were older and had a higher BMI. Compared with the data of the French Social Security, acromegalic patients showed a more precocious apparition of diabetes and prevalence was higher in each age group.Compared with non-diabetic acromegalic subjects, diabetic patients had a more prolonged evolution of acromegaly before diagnosis. The levels of GH and IGF1 were not significantly different between the two groups. Only hypertension was significantly more frequent in diabetic patients.ConclusionsIn our population, the prevalence of diabetes was estimated to be 22.3%. The GH and IGF1 levels did not appear as predictive factors for the presence of diabetes. On the contrary, age, BMI, and hypertension were significant risk factors as in the general population of type 2 diabetics.