Left ventricular remodelling index (LVRI) in various pathophysiological conditions: a real-time three-dimensional echocardiographic study

• Published in: Heart (British Cardiac Society) Vol. 93; no. 2; pp. 205 - 209
• Main Authors: De Castro, Stefano, Caselli, Stefano, Maron, Martin, Pelliccia, Antonio, Cavarretta, Elena, Maddukuri, Prasad, Cartoni, Domenico, Di Angelantonio, Emanuele, Kuvin, Jeffrey T, Patel, Ayan R, Pandian, Natesa G
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 01.02.2007; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: 3D echocardiography; 95% CI; 95% confidence interval; Adult; Analysis of Variance; Athletes; Biological and medical sciences; Blood pressure; Cardiac Imaging and Non-Invasive Testing; Cardiac Volume; Cardiology; Cardiology. Vascular system; Cardiomyopathy; Cardiomyopathy, Dilated - diagnostic imaging; Cardiomyopathy, Hypertrophic - diagnostic imaging; Cardiovascular disease; Cardiovascular system; Case-Control Studies; Datasets; Doppler effect; ECG; Echocardiography; Echocardiography, Three-Dimensional - methods; Ejection fraction; electrocardiogram; Electrocardiography; Female; Heart Ventricles - diagnostic imaging; Heart Ventricles - pathology; Humans; Hypertension; ICC; inter- and intra-class correlation coefficient; interquartile range; Investigative techniques, diagnostic techniques (general aspects); IQR; Ischemia; left ventricular ejection fraction; left ventricular end-diastolic volume; left ventricular end-systolic volume; left ventricular mass; left ventricular remodelling index; LV mass; LV remodelling; LV volumes; LVEDV; LVEF; LVESV; LVM; LVRI; Male; Medical sciences; Observer Variation; Patients; patients with dilated cardiomyopathy; patients with hypertrophic cardiomyopathy; Population; real-time three-dimensional echocardiography; RT3DE; Sports; Sports medicine; three-dimensional; Ultrasonic investigative techniques; Variance analysis; Ventricular Remodeling; volunteers; United States > US; Rome Italy; Italy; Sonography; Time study; Echocardiography; Tridimensional image; Index; Circulatory system; Cardiology; Real time; Phlebology; Left ventricle
• ISSN: 1355-6037; 1468-201X; 1468-201X
• DOI: 10.1136/hrt.2006.093997

Background: Various studies have reported a close correlation between real-time three-dimensional echocardiography (RT3DE) and cine magnetic resonance imaging studies for the assessment of cardiac volumes and mass. Objective: The aim of our study was to evaluate changes in left ventricular volumes and mass in subjects with different pathophysiological conditions. A ratio between left ventricular mass and end-diastolic volume (LVRI), detected by RT3DE, was used to describe various patterns of left ventricular remodelling. Methods: RT3DE was performed to calculate left ventricular end-diastolic (LVEDV) and end-systolic volume (LVESV), ejection fraction (LVEF) and mass in 220 selected subjects. Of these, 152 were healthy volunteers, 19 top-level rowers, 23 patients with dilated cardiomyopathy and 26 patients with hypertrophic cardiomyopathy. Off-line analysis was performed by two independent operators by tracing manual endocardial and epicardial borders of the left ventricle through eight cutting planes. Inter- and intra-observer variability were calculated. Results: Despite the increase in LV volume and mass in the rowers, LVRI remained unchanged compared with control subjects (p = 0.455), while significantly lower values were found patients with dilated cardiomyopathy (p<0.001) and significantly higher values in patients with hypertrophic cardiomyopathy (p<0.001). There was inter- and intra-observer variability. Conclusion: The LVRI may serve as a simple and useful indicator of left ventricular adaptation to physiological and pathological conditions.