Calciphylaxis in Man

A patient with renal failure developed widespread calcification in the thighs after the injection of iron-dextran (Imferon). This is considered as an example of calciphylaxis, a process in which calcium is laid down in parts of the body following the administration of a “challenger.” Iron-dextran is...

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Bibliographic Details
Published inBritish Medical Journal Vol. 2; no. 5658; pp. 670 - 672
Main Authors Rees, J. K. H., Coles, G. A.
Format Journal Article
LanguageEnglish
Published England British Medical Journal Publishing Group 14.06.1969
British Medical Association
BMJ Publishing Group LTD
Subjects
Adult
Aluminum
Blood
Calciphylaxis
Calcium
Calcium Phosphates - blood
Dosage
Humans
Hydroxides
Iron-Dextran Complex - adverse effects
Kidney Failure, Chronic - drug therapy
Male
Nandrolone - therapeutic use
Papers and Originals
Parathyroid Hormone - blood
Pathology
Phosphates
Prednisone - adverse effects
Radiography
Sensitization
Steroids
Thigh - diagnostic imaging
Thigh - pathology
Uremia - drug therapy
Online AccessGet full text
ISSN0007-1447
1468-5833
DOI10.1136/bmj.2.5658.670

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Summary:A patient with renal failure developed widespread calcification in the thighs after the injection of iron-dextran (Imferon). This is considered as an example of calciphylaxis, a process in which calcium is laid down in parts of the body following the administration of a “challenger.” Iron-dextran is a known challenger, and should be used with caution in uraemic subjects, who may be sensitized by high serum parathyroid hormone levels. Contributing factors may have been a high calcium/phosphate product, steroids, and the patient's immobility.
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ISSN:0007-1447
1468-5833
DOI:10.1136/bmj.2.5658.670