The role of glucocorticoids and corticotropin-releasing hormone regulation on anxiety symptoms and response to treatment

The stress response has been linked to the expression of anxiety and depression, but the mechanisms for these connections are under continued consideration. The activation and expression of glucocorticoids and CRH are variable and may hold important clues to individual experiences of mood disorders....

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Bibliographic Details
Published inEndocrine Connections Vol. 6; no. 2; pp. R1 - R7
Main Authors Raglan, Greta B, Schmidt, Louis A, Schulkin, Jay
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.02.2017
Bioscientifica
Subjects
anxiety
CRH
depression
glucocorticoids
PTSD
Review
PTSD
CRH
anxiety
glucocorticoids
depression
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ISSN2049-3614
2049-3614
DOI10.1530/EC-16-0100

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Summary:The stress response has been linked to the expression of anxiety and depression, but the mechanisms for these connections are under continued consideration. The activation and expression of glucocorticoids and CRH are variable and may hold important clues to individual experiences of mood disorders. This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations. In addition, it focuses on ways in which extra-hypothalamic glucocorticoids and CRH, often overlooked, may play important roles in the presentation of clinical disorders.
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ISSN:2049-3614
2049-3614
DOI:10.1530/EC-16-0100