Test–retest variability of intraocular pressure and ocular pulse amplitude for dynamic contour tonometry: a multicentre study

• Published in: British journal of ophthalmology Vol. 94; no. 4; pp. 419 - 423
• Main Authors: Fogagnolo, P, Figus, M, Frezzotti, P, Iester, M, Oddone, F, Zeppieri, M, Ferreras, A, Brusini, P, Rossetti, L, Orzalesi, N
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.04.2010; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Aged; Automation; Biological and medical sciences; Biometrics; Cataracts; Data collection; Female; Glaucoma; Glaucoma, Open-Angle - physiopathology; Humans; intraocular pressure (IOP); Intraocular Pressure - physiology; Male; Medical sciences; Middle Aged; Miscellaneous; Observer Variation; ocular pulse amplitude; Ophthalmology; Patients; primary open-angle glaucoma (POAG); reproducibility; Sensitivity and Specificity; Studies; Surgery; Tonometry; Tonometry, Ocular - methods; Visual Acuity - physiology; Switzerland; Amplitude; Eye; Ocular; Contour; Dynamics; Variability; Pulse; Tonometry; Ophthalmology; Intraocular pressure
• ISSN: 0007-1161; 1468-2079; 1468-2079
• DOI: 10.1136/bjo.2009.165142

AimsTo assess the test–retest variability of intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements utilising dynamic contour tonometry (DCT) and to evaluate possible influential factors.MethodsThe study included 350 consecutive subjects (175 glaucoma, 175 control; one eye per subject) from seven European centres. IOP was measured once with a Goldmann applanation tonometer (GAT) and twice by DCT (DCT1, DCT2) in a randomised sequence. OPA was also recorded for both DCT measurements. Differences (DCT1-DCT2; OPA1-OPA2; GAT-DCT1; GAT-DCT2) were assessed using the t test. The intraclass coefficient of correlation (ICC) and coefficient of variation (CoV) for DCT and OPA were calculated.ResultsDCT1 was 0.6±1.6 mm Hg higher than DCT2 (p<0.001); OPA1 was 0.1±0.7 mm Hg higher than OPA2 (p=0.02). Results were not influenced by randomisation test order. In both glaucoma and normal subjects, DCT and OPA showed ICC>0.90 and >0.76, and CoV=4.8–5.0% and 10.3–10.5%, respectively. DCT1 and 2 were 2.4±2.6 and 1.8±2.6 mm Hg higher respectively than GAT (p<0.001).DiscussionDCT test–retest variability was almost perfect for IOP and good for OPA. Tonometry measurements with DCT tended to be overestimated compared with GAT.