Use of the ISUP e-learning module improves interrater reliability in prostate cancer grading

• Published in: Journal of clinical pathology Vol. 77; no. 1; pp. 22 - 26
• Main Authors: Flach, Rachel N, Egevad, Lars, Eklund, Martin, van der Kwast, Theodorus H, Delahunt, Brett, Samaratunga, Hemamali, Suelmann, Britt B M, Willemse, Peter-Paul M, Meijer, Richard P, van Diest, Paul J
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.01.2024; BMJ Publishing Group LTD
• Subjects: Biopsy; Classification; EDUCATION; Education, Medical; Investigations; Laboratories; Online instruction; Original research; Pathology; PROSTATE; Prostate cancer; Surveillance; Tumors; Urologic Neoplasms; Urological cancer; Netherlands; PROSTATE; EDUCATION; Urologic Neoplasms; Education, Medical
• ISSN: 0021-9746; 1472-4146; 1472-4146
• DOI: 10.1136/jcp-2022-208506

AimsProstate cancer (PCa) grading is an important prognostic parameter, but is subject to considerable observer variation. Previous studies have shown that interobserver variability decreases after participants were trained using an e-learning module. However, since the publication of these studies, grading of PCa has been enhanced by adopting the International Society of Urological Pathology (ISUP) 2014 grading classification. This study investigates the effect of training on interobserver variability of PCa grading, using the ISUP Education web e-learning on Gleason grading.MethodsThe ISUP Education Prostate Test B Module was distributed among Dutch pathologists. The module uses images graded by the ISUP consensus panel consisting of 24 expert uropathologists. Participants graded the same 10 images before and after e-learning. We included those who completed the tests before and after training. We evaluated variation in PCa grading in a fully crossed study design, using linearly weighted kappa values for each pathologist, comparing them to other pathologists and to the ISUP consensus panel. We analysed the improvement in median weighted kappas before and after training, using Wilcoxon’s signed rank-test.ResultsWe included 42 pathologists. Inter-rater reliability between pathologists improved from 0.70 before training to 0.74 after training (p=0.01). When compared with the ISUP consensus panel, five pathologists improved significantly, whereas the kappa of one pathologist was significantly lower after training. All pathologists who improved significantly, graded with less than substantial agreement before training.ConclusionsISUP Prostate Test B e-learning reduces variability in PCa grading. E-learning is a cost-effective method for standardisation of pathology.