Aggregatibacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen

• Format: eBook Book
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: A. actinomycetemcomitans; accessory genes; adherence; adjunctive antibiotics; Aggregatibacter actinomycetemcomitans; antimicrobial activity; apoptosis; average nucleotide identity; bacteremia; biofilm; Biology, life sciences; cagE; cell lysis assay; core and accessory genes; core genes; cytokine binding factors; cytolethal distending toxin; cytotoxicity; damage/response framework; differentially expressed genes; endocarditis; endocytosis; essential oil; fimbriae; genomic islands; genotype; horizontal gene transfer; horseshoe crab; immune response; Infectious Diseases; infektionssjukdomar; inflammasome; JP2; JP2 clone of Aggregatibacter actinomycetemcomitans; JP2 genotype; JP2 in Caucasian; keratins; landscape ecology; leukotoxin; leukotoxin (LtxA); leukotoxin neutralization; LFA-1; lipopolysaccharides; localized aggressive periodontitis; localized aggressive periodontitis: animal studies: human studies; lymphocytes; Mathematics and Science; microbiological diagnosis; minimal bactericidal concentration; minimum inhibitory concentration; mRNA assay; n/a; nutrient limitation; organotypic gingival mucosa; Origanum vulgare; outer membrane vesicles; periodontal disease; periodontitis; principal component analysis; proteomic; proteomics; quantitative ELISA; Reference, Information and Interdisciplinary subjects; Research and information: general; RNA-Seq; RTX toxin; stress; taxonomy; virB1; virB4; virulence
• ISBN: 3039433768; 9783039433773; 3039433776; 9783039433766
• DOI: 10.3390/books978-3-03943-377-3

Aggregatibacter actinomycetemcomitans is a well-studied Gram-negative bacterium that can often be found in the oral cavity of young individuals. It has several virulence factors and a large genetic diversity, which results in both harmless and highly virulent genotypes. To determine the virulence potential of the isolated bacteria, genetic profiling is recommended. Advanced knowledge of the virulence mechanisms induced by this bacterium is important for the development of future personalized preventive and treatment strategies. The fifteen papers in this book provide a strong and relevant background that can contribute to the improvement of future diagnosis and research strategies.