Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

2+-activity of the molecularly homogeneous PFC→PAG type against two heterogeneous classes in several two-alternative choice tasks in freely-moving mice, we found that all task-related signals assayed were qualitatively present in all examined classes. However, PAG-projecting neurons most potently en...

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Published inbioRxiv
Main Authors Lui, Jan H, Nguyen, Nghia D, Grutzner, Sophie M, Darmanis, Spyros, Peixoto, Diogo, Wagner, Mark J, Allen, William E, Kebschull, Justus M, Richman, Ethan B, Ren, Jing, Newsome, William T, Quake, Stephen R, Luo, Liqun
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 03.10.2020
Cold Spring Harbor Laboratory
Edition1.3
Subjects
Calcium
Cognitive ability
Nervous system
Neurons
Neuroscience
Periaqueductal gray area
Prefrontal cortex
Reinforcement
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ISSN2692-8205
2692-8205
DOI10.1101/2020.03.14.991018

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Summary:2+-activity of the molecularly homogeneous PFC→PAG type against two heterogeneous classes in several two-alternative choice tasks in freely-moving mice, we found that all task-related signals assayed were qualitatively present in all examined classes. However, PAG-projecting neurons most potently encoded choice in cued tasks, whereas contralateral PFC-projecting neurons most potently encoded reward context in an uncued task. Thus, task signals are organized redundantly, but with clear quantitative biases across cells of specific molecular-anatomical characteristics. Competing Interest Statement The authors have declared no competing interest. Footnotes * ↵8 Lead Contact
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Competing Interest Statement: The authors have declared no competing interest.
ISSN:2692-8205
2692-8205
DOI:10.1101/2020.03.14.991018