Adaptive optics enhanced all-optical photoacoustic tomography
Abstract All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized c...
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| Published in | bioRxiv |
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| Main Authors | , |
| Format | Paper |
| Language | English |
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Cold Spring Harbor
Cold Spring Harbor Laboratory Press
15.01.2021
Cold Spring Harbor Laboratory |
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| ISSN | 2692-8205 2692-8205 |
| DOI | 10.1101/2021.01.13.426260 |
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| Abstract | Abstract All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues in vivo. Competing Interest Statement The authors have declared no competing interest. |
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| AbstractList | All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues in vivo. Abstract All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues in vivo. Competing Interest Statement The authors have declared no competing interest. |
| Author | Prevedel, Robert Czuchnowski, Jakub |
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| Cites_doi | 10.1107/S0021889800010219 10.1038/s41377-018-0036-7 10.1002/adom.202001337 10.1364/BOE.391980 10.1364/OL.42.000751 10.1088/0266-5611/26/11/115003 10.1038/nmeth.3925 10.1117/12.2509437.S 10.1038/lsa.2014.46 10.1364/OE.382526 10.1117/1.3619139 10.1016/j.pacs.2020.100223 10.1117/12.2551305 10.1117/1.3360308 10.1038/nmeth.4218 10.1364/AO.47.000561 10.1038/nphoton.2015.22 10.1364/AO.56.005039 |
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| Keywords | adaptive optics Photoacoustic tomography Fabry-Pérot sensors |
| Language | English |
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| References | Jathoul, Laufer, Ogunlade, Treeby, Cox, Zhang, Johnson, Pizzey, Philip, Marafioti (2021.01.13.426260v1.4) 2015; 9 Treeby, Cox (2021.01.13.426260v1.13) 2010; 15 Ida, Ando, Toraya (2021.01.13.426260v1.15) 2000; 33 Booth (2021.01.13.426260v1.9) 2014; 3 Treeby, Varslot, Zhang, Laufer, Beard (2021.01.13.426260v1.11) 2011; 16 Marques, Guggenheim, Ansari, Zhang, Beard, Munro (2021.01.13.426260v1.7) 2020; 28 Buchmann, Guggenheim, Zhang, Scharfenorth, Spannekrebs, Villringer, Laufer (2021.01.13.426260v1.14) 2017; 56 Ji (2021.01.13.426260v1.8) 2017; 14 Wissmeyer, Pleitez, Rosenthal, Ntziachristos (2021.01.13.426260v1.2) 2018; 7 Zhang, Laufer, Beard (2021.01.13.426260v1.3) 2008; 47 (2021.01.13.426260v1.10) 1994; 2 Wang, Yao (2021.01.13.426260v1.1) 2016; 13 Varu (2021.01.13.426260v1.5) 2014 Noack, Bogan, Willke (2021.01.13.426260v1.19) 2017; 42 Cui, Zuo, Wang, Deng, Luo, Ma (2021.01.13.426260v1.16) 2020 Sheppard, Guggenheim, Marques, Ansari, Zhang, Beard, Munro (2021.01.13.426260v1.20) 2020; 11240, International Society for Optics and Photonics, SPIE Czuchnowski, Prevedel (2021.01.13.426260v1.6) 2020 Treeby, Zhang, Cox (2021.01.13.426260v1.12) 2010; 26 Villringer, Gilani, Zhang, Pulwer, Steglich, Schrader, Laufer (2021.01.13.426260v1.17) 2019; 10878 Chen, Chen, Ma (2021.01.13.426260v1.18) 2020; 11 |
| References_xml | – volume: 33 start-page: 1311 issue: 6 year: 2000 end-page: 1316 ident: 2021.01.13.426260v1.15 article-title: Extended pseudo-Voigt function for approximating the Voigt profile publication-title: Journal of Applied Crystallography doi: 10.1107/S0021889800010219 – volume: 7 start-page: 1 issue: 1 year: 2018 end-page: 16 ident: 2021.01.13.426260v1.2 article-title: Looking at sound: optoacoustics with all-optical ultrasound detection publication-title: Light Sci. Appl doi: 10.1038/s41377-018-0036-7 – start-page: 2001337 year: 2020 ident: 2021.01.13.426260v1.6 article-title: Improving the sensitivity of planar fabry-pèrot cavities via adaptive optics and mode filtering publication-title: Advanced Optical Materials doi: 10.1002/adom.202001337 – year: 2014 ident: 2021.01.13.426260v1.5 publication-title: The optical modelling and design of fabry perot interferometer sensors for ultrasound detection, Ph.D. thesis, UCL (University College London) – volume: 11 start-page: 2607 issue: 5 year: 2020 end-page: 2618 ident: 2021.01.13.426260v1.18 article-title: Photothermally tunable fabry-pérot fiber interferometer for photoacoustic mesoscopy publication-title: Biomed. Opt. Express doi: 10.1364/BOE.391980 – volume: 42 start-page: 751 issue: 4 year: 2017 end-page: 754 ident: 2021.01.13.426260v1.19 article-title: Higher-order laguerre–gauss modes in (non-) planar four-mirror cavities for future gravitational wave detectors publication-title: Opt. Lett doi: 10.1364/OL.42.000751 – volume: 26 start-page: 115003 issue: 11 year: 2010 ident: 2021.01.13.426260v1.12 article-title: Photoacoustic tomography in absorbing acoustic media using time reversal publication-title: Inverse Problems doi: 10.1088/0266-5611/26/11/115003 – volume: 13 start-page: 627 issue: 8 year: 2016 ident: 2021.01.13.426260v1.1 article-title: A practical guide to photoacoustic tomography in the life sciences publication-title: Nat. Methods doi: 10.1038/nmeth.3925 – volume: 10878 start-page: 28 year: 2019 end-page: 33 ident: 2021.01.13.426260v1.17 article-title: Development of tuneable Fabry-Pèrot sensors for parallelised photoacoustic signal acquisition publication-title: Photons Plus Ultrasound: Imaging and Sensing 2019 doi: 10.1117/12.2509437.S – volume: 3 start-page: e165 issue: 4 year: 2014 end-page: e165 ident: 2021.01.13.426260v1.9 article-title: Adaptive optical microscopy: the ongoing quest for a perfect image publication-title: Light: Science & Applications doi: 10.1038/lsa.2014.46 – volume: 28 start-page: 7691 issue: 5 year: 2020 end-page: 7706 ident: 2021.01.13.426260v1.7 article-title: Modelling fabry-pèrot etalons illuminated by focussed beams publication-title: Opt. Express doi: 10.1364/OE.382526 – volume: 2 year: 1994 ident: 2021.01.13.426260v1.10 article-title: 60825–1, radiation safety of laser products and systems publication-title: British Standards Institute – volume: 16 start-page: 090501 issue: 9 year: 2011 ident: 2021.01.13.426260v1.11 article-title: Automatic sound speed selection in photoacoustic image reconstruction using an autofocus approach publication-title: Journal of biomedical optics doi: 10.1117/1.3619139 – start-page: 100223 year: 2020 ident: 2021.01.13.426260v1.16 article-title: Adaptive photoacoustic computed tomography publication-title: Photoacoustics doi: 10.1016/j.pacs.2020.100223 – volume: 11240, International Society for Optics and Photonics, SPIE start-page: 63 year: 2020 end-page: 71 ident: 2021.01.13.426260v1.20 article-title: Interrogation of Fabry-Pèrot ul-trasound sensors with Bessel beams publication-title: Photons Plus Ultrasound: Imaging and Sensing 2020 doi: 10.1117/12.2551305 – volume: 15 start-page: 021314 issue: 2 year: 2010 ident: 2021.01.13.426260v1.13 article-title: k-wave: Matlab toolbox for the simulation and reconstruction of photoacoustic wave fields publication-title: Journal of biomedical optics doi: 10.1117/1.3360308 – volume: 14 start-page: 374 issue: 4 year: 2017 end-page: 380 ident: 2021.01.13.426260v1.8 article-title: Adaptive optical fluorescence microscopy publication-title: Nat. Methods doi: 10.1038/nmeth.4218 – volume: 47 start-page: 561 issue: 4 year: 2008 end-page: 577 ident: 2021.01.13.426260v1.3 article-title: Backward-mode multiwavelength photoa-coustic scanner using a planar fabry-perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues publication-title: Appl. Opt doi: 10.1364/AO.47.000561 – volume: 9 start-page: 239 issue: 4 year: 2015 ident: 2021.01.13.426260v1.4 article-title: Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter publication-title: Nat. Photonics doi: 10.1038/nphoton.2015.22 – volume: 56 start-page: 5039 issue: 17 year: 2017 end-page: 5046 ident: 2021.01.13.426260v1.14 article-title: Characterization and modeling of fabry–perot ul-trasound sensors with hard dielectric mirrors for photoacoustic imaging publication-title: Appl. Opt doi: 10.1364/AO.56.005039 |
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| Snippet | Abstract All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling... All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the... |
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