Adaptive optics enhanced all-optical photoacoustic tomography

Abstract All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized c...

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Bibliographic Details
Published inbioRxiv
Main Authors Czuchnowski, Jakub, Prevedel, Robert
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 15.01.2021
Cold Spring Harbor Laboratory
Edition1.1
Subjects
Bioengineering
Optics
Tomography
Ultrasound
adaptive optics
Photoacoustic tomography
Fabry-Pérot sensors
Online AccessGet full text
ISSN2692-8205
2692-8205
DOI10.1101/2021.01.13.426260

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Summary:Abstract All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues in vivo. Competing Interest Statement The authors have declared no competing interest.
Bibliography:SourceType-Working Papers-1
ObjectType-Working Paper/Pre-Print-1
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Competing Interest Statement: The authors have declared no competing interest.
ISSN:2692-8205
2692-8205
DOI:10.1101/2021.01.13.426260