Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier

• Published in: International Journal of Biomaterials Vol. 2014; no. 2014; pp. 21 - 27
• Main Authors: de Camargo Drago, Bruno, Donizetti Herculano, Rondinelli, Ferreira Cinman, José Luiz, Guedes Mazalli, Alexandre Vinicius, Roberto de Barros, Natan, Lopes, Rute, Romeiro Miranda, Matheus Carlos, Azevedo Borges, Felipe, Jaques Ogawa, Guilherme, Dias Murbach, Heitor, Gonçalves da Silva, Rosângela
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Wiley
• Subjects: Aqueous solutions; Chemical properties; Chemical reactions; Ciprofloxacin; Colleges & universities; Crystal structure; Drug delivery systems; Drug dosages; Fourier transforms; Gram-positive bacteria; Health aspects; Hevea brasiliensis; Hydrogen; Latex; Membranes; Observations; Proteins; Rubber; X-ray diffraction; X-ray spectroscopy
• ISSN: 1687-8787; 1687-8795
• DOI: 10.1155/2014/157952

Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.