Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease

• Published in: Clinical Medicine Insights. Cardiology Vol. 2017; pp. 1 - 9-014
• Main Authors: Tácito, Lúcia Helena Bonalume, Yamada, Lilian Nakachima, de Souza Pinhel, Marcela Augusta, Yugar-Toledo, Juan Carlos, Souza, Dorotéia Rossi Silva
• Format: Journal Article
• Language: English
• Published: London, England Libertas Academica 2017; SAGE Publications; Sage Publications Ltd; SAGE Publishing
• Subjects: Cardiovascular disease; Health risk assessment; Lipids; Low density lipoprotein; Original Research; Studies; Womens health; United States > US; apolipoprotein E; cholesterol; postprandial triglycerides; postmenopause; Coronary artery disease
• ISSN: 1179-5468; 1179-5468
• DOI: 10.1177/1179546817731110

This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the APOE*4 allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the APOE*4 allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. In this case, the study of subgroups, considering the APOE*3/3 and APOE*3/4 genotypes, suggests that the APOE*4 allele is not implicated in the variations of the lipid profile of patients and determined an increase in the production levels of HDL-C and a reduction in TG highly benefiting the control group compared with APOE*3/3 genotype. The metabolic kinetics of TG, although with the same pattern between groups, and the presence of the APOE*4 allele are suggested to be associated with accelerated clearance compared with APOE*3 allele in non-CAD group.