DNA Damage, Neurodegeneration, and Synaptic Plasticity

• Published in: Journal of neural transplantation & plasticity Vol. 2016; pp. 20 - 21-002
• Main Authors: Merlo, Daniela, Cuchillo-Ibañez, Inmaculada, Parlato, Rosanna, Rammes, Gerhard
• Format: Journal Article
• Language: English
• Published: United States Hindawi Limiteds 01.01.2016; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Wiley
• Subjects: Advertising executives; Alzheimer's disease; Animals; Chromatin; DNA; DNA damage; DNA Damage - physiology; DNA methylation; Epigenetics; Genetic research; Humans; Kinases; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nervous system diseases; Neurodegeneration; Neuronal Plasticity - physiology; Physiological aspects
• ISSN: 0792-8483; 2090-5904; 1687-5443; 1687-5443
• DOI: 10.1155/2016/1206840

[...]the emerging roles played in memory and neurodegeneration by different factors involved in the stress response, chromatin remodeling, and nucleolar function are specifically addressed. [...]they stress the evidence that the mechanisms controlling DNA damage in neurons may vary depending on the brain region and suggest the need for further investigation to determine whether differences in the response to DNA damage underlie the brain-region selectivity observed in neurodegenerative diseases. [...]the authors propose Fyn kinase blockers Masitinib and Saracatinib as effective molecules in treating AD symptoms in experimental mouse models of the disease.