Rotaviruses and Rotavirus Vaccines

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2024
• Subjects: actin; antibody; behavioral responses; Biology, life sciences; cell culture; CNS; cross-species transmission; culture adaptation; cytoskeleton; diarrhea; early life; ERK1/2; evolution; expression vector; G9P; gastroenteritis; genome packaging; genome segment assortment; genotype; glycans; high-throughput screening; histo-blood group antigens; human rotavirus; layered immunity; lipid droplets; lipid nanoparticles; live attenuated rotavirus vaccine; MAPK signaling pathway; maternal antibodies; Mathematics and Science; microneutralization assay; microtubule; minigenome; ML241 (hydrochloride); molecular characteristics; molecular motors; Mozambique; mRNA vaccine; n/a; neutralizing antibody; next-generation sequencing; NF-κB; nonstructural protein 2; NSP2; NSP4 E6 genotype; NSP5; P-type reassortment; particle assembly; pathogenicity; plant virus adjuvants; point mutation; porcine rotavirus; porcine rotavirus A (RVA); pre-existing immunity; prevalence; probiotics; recombinant antigen; recombinant vaccine; Reference, Information and Interdisciplinary subjects; regulatory T cell; replication; replication kinetics; reporter assay; Research and information: general; reverse genetics; reverse genetics system; RNA-dependent RNA polymerase; Rotarix; rotavirus; rotavirus A; rotavirus infection; rotavirus vaccine; RV3-BB vaccine; serial passage; serotypes; shedding; sickness symptoms; small-animal model; South Africa; spherical particles; structural protein VP7; structurally modified plant viruses; Sub-Saharan Africa; T cell; tobacco mosaic virus; triple-reassortant; vaccine; viroplasm; virus isolation; VP2; VP4
• ISBN: 3725827893; 9783725827893; 9783725827909; 3725827907
• DOI: 10.3390/books978-3-7258-2790-9

Rotaviruses are a major cause of acute gastroenteritis in infants and young children and in the young of various mammalian and avian hosts. Although rotavirus-associated morbidity and mortality have significantly decreased since the introduction of rotavirus vaccines into childhood immunization programs, the efficacy of these vaccines is suboptimal in developing countries where they are needed most. Our insight into the molecular epidemiology of rotaviruses has benefited greatly from the application of advanced sequencing and bioinformatic techniques. Combined with the recent development of plasmid-only-based reverse genetics systems, powerful new approaches are now available for the study of all aspects of rotavirus biology, including their replication strategy, the structure and function of their proteins, and their ability to suppress immune responses. Moreover, these technologies provide a possible path for the development of new generations of more effective rotavirus vaccines. This Special Issue of Viruses reviews and explores recent progress made in the analysis of rotavirus replication, viral diversity, genotype–phenotype assignment, correlates of protection, biotechnology, and the development of alternative candidate vaccines.