Central Limit Theorems of a Recursive Stochastic Algorithm with Applications to Adaptive Designs

• Published in: arXiv.org
• Main Author: Zhang, Li-Xin
• Format: Paper Journal Article
• Language: English
• Published: Ithaca Cornell University Library, arXiv.org 18.02.2016
• Subjects: Adaptive algorithms; Algorithms; Approximation; Asymptotic methods; Asymptotic properties; Differential equations; Estimating techniques; Gaussian process; Mathematical analysis; Mathematics - Probability; Medical research; Normality; Random variables; Randomization; Theorems
• ISSN: 2331-8422
• DOI: 10.48550/arxiv.1602.05708

Stochastic approximation algorithms have been the subject of an enormous body of literature, both theoretical and applied. Recently, Laruelle and Pagès (2013) presented a link between the stochastic approximation and response-adaptive designs in clinical trials based on randomized urn models investigated in Bai and Hu (1999, 2005), and derived the asymptotic normality or central limit theorem for the normalized procedure using a central limit theorem for the stochastic approximation algorithm. However, the classical central limit theorem for the stochastic approximation algorithm does not include all cases of its regression function, creating a gap between the results of Laruelle and Pagès (2013) and those of Bai and Hu (2005) for randomized urn models. In this paper, we establish new central limit theorems of the stochastic approximation algorithm under the popular Lindeberg condition to fill this gap. Moreover, we prove that the process of the algorithms can be approximated by a Gaussian process that is a solution of a stochastic differential equation. In our application, we investigate a more involved family of urn models and related adaptive designs in which it is possible to remove the balls from the urn, and the expectation of the total number of balls updated at each stage is not necessary a constant. The asymptotic properties are derived under much less stringent assumptions than those in Bai and Hu (1999, 2005) and Laruelle and Pagès (2013).